Kratom and Alcohol: Dangers, Effects & Treatment

Written by The Recovery Village

& Medically Reviewed by Dr. Kevin Wandler, MD

Medically Reviewed

Last updated: 09/26/2024

This article was reviewed by a medical professional to guarantee the delivery of accurate and up-to- date information. View our research policy.

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Last Updated - 09/26/2024

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Key Takeaways

  • Combining kratom and alcohol can lead to heightened sedation, respiratory depression, and other serious health risks.
  • Scientific research on kratom and alcohol interactions is limited but suggests the potential for harm reduction in alcohol use disorders.
  • Animal studies on kratom and alcohol provide foundational insights, but human studies are needed for conclusive evidence.
  • Health professionals advise against mixing kratom and alcohol due to unpredictable and potentially severe side effects.

Risks of Combining Kratom and Alcohol

Mixing kratom, a tropical tree with stimulant and sedative properties, with alcohol, a depressant, can be hazardous due to their overlapping effects. The combination significantly increases sedation, raising the risk of respiratory depression and other serious health issues.

Physiological Risks of Mixing Kratom with Alcohol

Depressant Effects on the Central Nervous System

Kratom and alcohol both depress the central nervous system (CNS), and their simultaneous use significantly amplifies their sedative effects. This can result in excessive sedation, impaired coordination, and an increased risk of accidents due to reduced motor function.

Risk of Respiratory Depression

Life-Threatening Breathing Problems

One of the most severe risks of combining kratom and alcohol is respiratory depression, where breathing slows down dangerously. This can lead to unconsciousness, respiratory failure, and, in extreme cases, coma or death. The combined use of these substances magnifies this danger.

Strain on the Liver and Kidneys

Increased Risk of Organ Damage

Both substances place a heavy load on the liver and kidneys, increasing the risk of organ damage, especially with frequent use. This can lead to gastrointestinal issues and long-term health problems.

Immediate Physical Effects

Short-Term Symptoms and Risks

Users may experience nausea, dizziness, and a paradoxical increase in euphoria and relaxation when combining kratom and alcohol. However, these short-term effects are outweighed by the significant health risks, such as respiratory depression and organ strain.

Expert Recommendations

Strong Warnings Against Use

Given the serious health risks, experts strongly advise against mixing kratom and alcohol. The potential for life-threatening complications and long-term damage makes this combination extremely dangerous.

Psychological Impacts of Mixing Kratom with Alcohol

Cognitive and Motor Impairment

The combination of kratom and alcohol can result in dangerous psychological effects. While some users report heightened euphoria and relaxation, the interaction often leads to excessive drowsiness, impaired cognitive function, and reduced motor skills, increasing the risk of accidents and injuries.

Long-Term Mental Health Concerns

Substance Use and Cognitive Decline

Chronic use of kratom and alcohol raises concerns about long-term mental health. Regularly combining these substances can lead to substance use disorders, cognitive impairment, and other psychological issues. There is also an increased risk of respiratory depression and overdose, which may have fatal consequences.

Expert Advice on Avoidance

Protecting Psychological and Physical Health

Given the significant risks, experts strongly recommend avoiding the combination of kratom and alcohol. The dangers of addiction, cognitive decline, and mental health issues make this mix particularly hazardous to overall health.

Research on Kratom and Alcohol Interactions

Animal Research Highlights Potential Risks and Benefits

Animal studies have provided valuable insights into the effects of kratom, especially regarding its opioid-like properties and potential interactions with alcohol.

Findings from Animal Studies

One study focused on the effects of lyophilized kratom tea on mice, highlighting the role of compounds like mitragynine, speciociliatine, and paynantheine. While this research emphasizes kratom’s opioid-like effects, it also suggests potential complexity in its interaction with alcohol.

Need for Further Research

Further research is essential to clarify how kratom’s active alkaloids impact alcohol metabolism and the body’s response to alcohol. Such studies will help create clear safety guidelines for concurrent use.

Implications for Medical Providers

Medical providers should be aware of the growing prevalence of substance use disorders in individuals who consume kratom, including those with alcohol use disorders. This awareness can improve patient screenings and ensure proper care for individuals combining these substances.

Foundation for Future Studies

Current animal research serves as a foundation for future investigations. Additional studies are needed to fully understand the implications of kratom and alcohol use together.


Insights from Human Studies on Kratom and Alcohol Interaction

Limited Human Research

Human studies on the interaction between kratom and alcohol are still in their early stages, with most research being observational. The FDA’s announcement of a Human Abuse Potential (HAP) study is a significant step forward, showing that kratom can be safely consumed in controlled doses. This opens the door for more in-depth human studies on the dependency and addiction risks when using kratom alongside alcohol.

Focus of Recent Studies

Recent studies, such as those published by Frontiers in Pharmacology, have primarily focused on kratom’s self-reported benefits, such as pain relief, improved mood, and its role in managing dependencies. However, specific interactions between kratom and alcohol remain largely unexplored.

Neuropsychiatric Effects and Correlations

A study from PubMed identified neuropsychiatric effects, such as cognitive decline, as a potential consequence of combining alcohol and kratom. However, more research is needed to establish direct correlations between these substances.

The SAGE Journals have also noted a higher prevalence of alcohol use disorders among individuals who use kratom, suggesting a possible connection that warrants further exploration.

Need for Controlled Clinical Trials

While existing human studies provide initial insights, there is a clear need for controlled clinical trials. Such trials will be crucial in understanding the full range of physiological and psychological effects associated with the concurrent use of kratom and alcohol.

Safety Considerations for Kratom and Alcohol Consumption

Emphasis on Safety

When it comes to using kratom in conjunction with alcohol, safety should be the top priority. The combination of these substances is highly discouraged due to the significant potential for serious health risks.

Individual Effects of Kratom and Alcohol

Amplification of Harmful Effects

Both kratom and alcohol can be harmful to the body on their own, but their effects may become dangerously amplified when combined. This can lead to increased strain on critical organs such as the liver, kidneys, and cardiovascular system. The combination can also worsen the individual side effects of each substance, making the risks more severe.

Importance of Caution and Professional Advice

Avoiding Combined Use

Given the lack of comprehensive safety data and the clear potential for serious adverse outcomes, individuals are strongly advised to avoid mixing kratom with alcohol. Consulting with a healthcare professional is essential for anyone considering using either or both substances, as they can offer personalized advice based on an individual’s health status.

Prioritizing Health and Safety

Awareness of the risks and prioritizing one’s health and safety is crucial when considering the use of these substances. The potential for life-threatening effects makes caution and professional guidance imperative.

If there is any consideration of using these substances together, it is crucial to consult with a healthcare provider first. The US Food and Drug Administration (FDA) does not regulate kratom for safety, further underscoring the importance of caution and professional medical advice.

Seeking Addiction Treatment

If you’re seeking addiction treatment for yourself or a loved one, The Recovery Village Cherry Hill at Cooper is here to help. Our facility is conveniently located within the heart of New Jersey, under 20 minutes from Philadelphia. 

We offer a full range of treatment options, including medical detox, inpatient care, partial hospitalization programming, and intensive outpatient services. Our state-of-the-art inpatient facility includes specialized options for trauma, such as EMDR, and a specialty track for veterans and first responders.

Contact Us for Support

If you or a loved one are ready to begin the journey toward a substance-free life, we’re standing by to take your call. Reach out to our Recovery Advocates to learn more about our treatment programs and find a plan that works well for your specific needs and situation.

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